A simple and efficient protocol for the synthesis of quinolines catalyzed by chloramine-T

Quinoline scaffold are found in many natural products and they exhibit remarkable biological activities like Antimalerial, antibacterial, antiasthmatic, antihypertensive, anti-inflammatory agents and antiobesity. Aryl-substituted quinolines act as ligands for 5-lipoxygenase , tyrosine kinase , leukotriene 11 and other receptors. Furthermore, polyquinolines were shown to undergo hierarchical self-assembly into nanostructures with promising electronic and photonic properties. A variety of methods such as Doebner-von Miller, Skraup, Combes, Friedlander and Knorr synthesis have been used for preparation of quinolines and their derivatives. Therefore, the synthesis of quinoline derivatives attracted many researchers and various methods have been developed using a variety of catalysts and conditions. Among them, Friedlander annulations are one of the simplest and most straightforward protocols. This method involves a condensation and cyclization between a ketone possessing a methylene group and an aromatic 2-aminoaldehyde or ketone. However, many of these methods have some drawbacks such as high reaction temperature (150-200C), use of expensive catalysts and extended reaction times. As part of our research program in developing synthetic methodologies , herein we report, the synthesis of